![]() This response starts with sensing of danger by pattern-recognition receptors on the immune competent cells and endothelium. In critical illness, the acute immune response is organized and executed by innate immunity influenced by the neuroendocrine system. ![]() critical illness) remain high despite advances in diagnostic and organ supporting possibilities in intensive care units. The mortality and morbidity in SIRS and sepsis (i.e. ![]() The host inflammatory response in SIRS and sepsis is similar and may lead to multiple organ dysfunction syndrome (MODS) and ultimately death. The systemic immune response induced by non-infectious agents is called systemic inflammatory response syndrome (SIRS) and infection-induced systemic immune response is called sepsis.
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